Glemid-5 Tabs ( Glibenclamide 5mg ) Carton

During short-term treatment, glibenclamide increases insulin secretion from functioning pancreatic islet β-cells (pancreatic effect) whereas during long-term treatment its main action appears to be enhancements of insulin action on peripheral tissues and reduction of glucose outpost from liver (extrapancreatic effects).

Clinical Pharmacology

Non-steroidal anti-inflammatory agents and other drugs that are highly protein bound, as salicylates, sulfonamides, chloramphenicol, probenecid, coumarin derivates, beta-adrenergic blocking agents, ACE inhibitors, anabolic steroids, fenfluramine, miconazole, phenylbutazone, fluoxetine, biguanide preparations reserpine, PAS, tetracyclines are known to potentiate hypoglycaemic in patients under treatment with glibenclamide. Chronic alcoholism and chronic abuse of laxatives may lead to deterioration of the control of diabetes.